Cocaine pupil4/17/2023 ![]() Application of cocaine drops will dilate the unaffected iris but not the Horner iris. Cocaine drops block the reuptake of NE at the sympathetic nerve terminal to the iris dilator muscle, and AC acts as an agonist to the receptors of the iris dilator muscle, which are hypersensitive in Horner syndrome due to denervation. Ten percent cocaine eye drops are used for patients under age 2, and apraclonidine (AC) eye drops for older patients (apnea, drowsiness, and unresponsiveness can occur in young patients with AC application). Neuroblastoma (9%) and neurologic neoplasms (9%) were the next leading causes.Ĭhildren in our practice who are suspected to have Horner syndrome undergo an eye drop test. In the largest published series of pediatric patients with Horner syndrome-published by CHOP Ophthalmology-no cause was found in 36%. The differential diagnosis of Horner syndrome in children is different than adults and includes neuroblastoma and other upper chest/lower neck masses, carotid and brainstem lesions, and brachial plexus birth trauma, all of which can damage the sympathetic chain. The sympathetic neuron chain releases norepinephrine (NE), a pupil dilator, and when it is not present, the pupil remains small, and the upper lid droops. Horner syndrome reflects a remote process, interfering somewhere along the sympathetic chain that runs from the hypothalamus in the brain, down the cervical spinal cord, across the upper chest, returning up along the anterior neck/carotid plexus, and back to the eye. ![]() The generally subtle findings of the syndrome, and the fact it does not impact vision, can delay the diagnosis and the time needed to explore its serious potential causes. Less commonly noted findings include facial anhidrosis and mild lower eyelid ptosis (elevation). The typical presentation of Horner syndrome includes unilateral ptosis and miosis. However, the most concerning condition in the differential diagnosis of a child with anisocoria is Horner syndrome, a loss of the sympathetic tone to the eye (oculo-sympathetic paresis). Most of these patients are diagnosed with physiologic anisocoria and followed conservatively without need for further evaluation. Vision, eye movements, fundi, and general examination were normal.ĭiscussion: Anisocoria is a frequent referral and chief complaint in the ophthalmology clinics at CHOP. Case: A 10-month-old female infant was referred to the Neuro-ophthalmology clinic at Children’s Hospital of Philadelphia for a new-onset lid ptosis and pupillary miosis on the right side. London: Elsevier Publishing 2019:438, with permission. Liu, Volpe, and Galetta’s Neuro- Ophthalmology: Diagnosis and Management. ![]() Figure 1: From Liu GT, Volpe NJ, Galetta SL.
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